Drug-induced autoimmune hemolytic anemia is a form of hemolytic anemia.
In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. Drugs that can cause this type of hemolytic anemia include:
- Cephalosporins (a class of antibiotics) - most common cause
- Dapsone
- Levodopa
- Levofloxacin
- Methyldopa
- Nitrofurantoin
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Phenazopyridine (pyridium)
- Quinidine
Penicillin in high doses can induce immune mediated hemolysis via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.
The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.
Video Drug-induced autoimmune hemolytic anemia
See also
- List of circulatory system conditions
- List of hematologic conditions
Maps Drug-induced autoimmune hemolytic anemia
References
Source of the article : Wikipedia
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