The relationship between antidepressant use and suicide risk is the target of medical research. Studies have shown that the use of multiple antidepressants correlates with an increased risk of suicide in some patients, and this problem has been serious enough to warrant government intervention in some places to label a greater likelihood of suicide as a risk of antidepressant use. The circumstances under which this may occur are unclear, and other studies have shown that antidepressants treat suicidal ideals.
Video Antidepressants and suicide risk
Higher risk for teenagers
People under 24 who suffer from depression are warned that the use of antidepressants may increase the risk of thoughts and behaviors for suicide. Federal health officials announced proposed changes to the label on antidepressants in December 2006 to alert people of this danger.
The FDA warns against the use of Paxil for depression of children and adolescents who support Prozac.
SSRI prescriptions for children and adolescents decline after US and European regulatory agencies issue a warning about possible suicidal risks with antidepressant use in pediatric patients, and this decrease is associated with an increase in suicide rates among children and adolescents in the United States with 14% increased, and a 50% increase in the Netherlands.
A 2016 review of 70 clinical trials of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) included about 18,500 subjects and depended on clinical reports as well as available data looking at four outcomes - death, suicide, aggressive behavior, and agitation - and found that while data were not sufficient to draw strong conclusions, adults who took these drugs did not appear to be at high risk for any of the four outcomes, but for children, the risk of suicide and for aggression doubled. The authors express frustration with incomplete reporting and lack of access to data, and with some aspects of clinical trial design.
Maps Antidepressants and suicide risk
Warning
The Food and Drug Administration (FDA) requires "black box warning" on all SSRIs, stating that they double the suicidal rate (from 2 in 1,000 to 4 in 1,000) in children and adolescents. It is still controversial whether the increased risk of suicide is due to the drug (paradoxical effect) or part of the depression itself (ie antidepressants allow those very depressed - which would normally be paralyzed by their depression - to be more alert). and acts suicide before fully recovering from their episodes of depression). Increased risk for suicide and suicidal behavior among adults under 25 approaches seen in children and adolescents. Young patients should be closely monitored for signs of suicidal ideation or behavior, especially within the first eight weeks of therapy. Sertraline, a tricyclic agent and venlafaxine were found to increase the risk of attempted suicide in adolescents with severe depression in Medicaid.
Increased risk of discontinuing drugs
A 2009 study showed an increased risk of suicide after initiation, titration, and treatment interruption. A study of 159,810 users either amitriptyline, fluoxetine, paroxetine or dothiepin found that the risk of suicidal behavior increased in the first month after starting antidepressants, especially during the first 1 to 9 days.
Prevalence
On September 6, 2007, the Centers for Disease Control and Prevention reported that suicide rates among American adolescents, (especially girls, 10 to 24 years), increased by 8% (2003-2004), the biggest jump in 15 years, to 4,599 suicides in the United States ages 10 to 24 in 2004, from 4,232 in 2003, provided a suicide rate of 7.32 per 100,000 people of that age. The previous level dropped to 6.78 per 100,000 in 2003 from 9.48 per 100,000 in 1990. Jon Jureidini, a critic of this study, said that the US "2004 suicide rate was compared simplistically with the previous year, rather than examining several trend changes year". It has been noted that the pitfalls of such attempts to conclude a trend by using only two data points (2003 and 2004) are further indicated by the fact that, according to new epidemiological data, suicide rates in 2005 in children and teens actually decline despite the continued decline of SSRI recipes. "It's risky to draw conclusions from a limited ecological analysis of year-to-year fluctuations isolated in prescription antidepressants and suicides.
One promising epidemiological approach is to examine the relationship between the tendency of psychotropic drug use and suicide over time in a large number of small geographic areas. Until more detailed analysis is known, caution dictates a delay in the assessment of the public health effects of FDA warnings. â € Å" Subsequest follow-up research has supported the hypothesis that antidepressant drugs reduce the risk of suicide.
Antidepressants lower the risk of suicide
Source of the article : Wikipedia
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